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The collection of symptoms known as Klinefelter syndrome was first put together in 1942 by a young doctor in Philadelphia called Harry Klinefelter. He described 9 men who had breast development, small testicles with no sperm in their semen, and a blood test revealed raised levels of the factors (gonadotrophins) which try to stimulate the testicles to produce more of the male hormone (testosterone) and greater numbers of sperm.