Having previously completed a postgraduate diploma and master of Nursing at City, University of London and a Bachelor of Science (Hons) from Brunel University London. Brien now focuses his efforts on endocrine-related Research and clinical practice. Research and clinical interests include; patients with Klinefelter syndrome, chromosome aneuploidies and reproductive endocrinology. 

PhD Topic: 

Klinefelter Syndrome (KS) is the most common chromosome aneuploidy in men.  It affects 1 in 600 men, but 50-75% of men with KS go undiagnosed in their lifetime. The overall impact of a diagnosis of KS is multifaceted, with a high disease burden for both patients and NHS services due to uncontrolled symptoms, lack of timely diagnosis and current management guidelines. The impact of living with KS is profound, resulting in an increased risk of mortality and a significantly impaired quality of life.

Titled, Quality of life in Adult males with Klinefelter syndrome, Brien’s research is looking to understand the lived experiences of patients with Klinefelter syndrome, developing a new understanding of how Klinefelter syndrome impacts the quality of life. The information gained from upcoming studies will help guide the development and validation of a new health scale. The novel health scale will be used to accurately measure Health-related quality of life in adult males with Klinefelter syndrome. Future research will be conducted to implement this research into clinical practice.