Klinefelter syndrome (KS) patients younger than 16 should not be offered fertility preservation, according to a new evidence review.
NEW YORK (Reuters Health) – Klinefelter syndrome (KS) patients younger than 16 should not be offered fertility preservation, according to a new evidence review.
Germ cell retrieval rate by testicular sperm extraction (TESE) is far lower in these younger KS patients compared to those aged 16 to 30, Dr. Sebastian Franik of Radboudumc in Nijmegen, the Netherlands, and colleagues report in Human Reproduction, online July 13.
“Despite the current evidence that testicular degeneration seems to accelerate with the onset of puberty, there is no evidence that spermatogenesis seems to be impaired by this degeneration,” Dr. Franik told Reuters Health by email.
“There is no need for early fertility preservation before or during puberty,” he added. “Early fertility preservation might even lower the chances for spermatogenesis by removing stem cells that would have had developed into sperm otherwise.”