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Alternative to testosterone?

For some XXY folk, testosterone is not the answer.

With the more recent openess about the subject of gender, the KSA has become increasingly aware  that some XXY folk feel that they do not fit in the gender binary. While most feel male, others identify as neither gender, both genders or female. Gender fluid is an expression which is often used.

The letter below explains the situation of one member:

I started off at Charing Cross Hospital, Gender Identity Clinic (GIC), this is where I received my XXY diagnosis in 1998. In 2005/6 I saw two different Endocrinologists, this is when I tried Testosterone (T), that caused me to have a breast biopsy, because my breasts grew and the left one developed lumps. Also mentally the “T” took me to a type of living bereavement as I felt the XX side was dying. hence the “T” was ceased. Around 2008 via another Gender doctor, in desperation I started to take Oestrogen (O), but obtained it via the internet, at the time I was still having yearly checks with the Breast centre. The “O” made me feel generally unwell with a type of opposite XY bereavement, but as it was not a prescribed hormone, I did not trust what I was taking so again I ceased. After this I returned again to see other Gender related doctors, and gave up around 2011 as I was hitting a brick wall. Before it is too late I would like Oestrogen prescribe to me. Not because I want to become female, as I am that already. But, having tried “T” and it is not for me, I can not understand why as an XXY person. I have to visit a “GIC” and go down the road of living and working as a female….this is not me.

This member feels that neither their chromosomes nor their body are typically male or female. They feel both male and female. They can access testosterone easily (on prescription) but they have to go to a Gender Identity Clinic to access oestrogen.


This is not an isolated case. A number of KSA members have some level of gender identity issue. While some are able to embrace their differences, others find it more difficult.

Although testosterone is beneficial for most of those diagnosed with KS/XXY, it should not be assumed that it is right for everyone. There needs to be more consideration of what will suit that particular person. 

All KS/XXY people should be made aware that testosterone will have an effect on their personalities as well as their bodies. For men who want to become more virile, testosterone can have a very positive effect. For those who are gender fluid, the changes may not be welcomed.

Clearly there needs to be more discussion and research into this area.